Methods and compositions for preventing and treating neutrophil-mediated diseases
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United States of America Patent
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Issued Date -
Oct 31, 2002
app pub date -
Feb 25, 2002
filing date -
Feb 23, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention relates to methods and pharmaceutical compositions for the treatment of neutrophil-mediated diseases in humans and animals. More particularly, the present invention is concerned with methods and compositions for preventing and treating diseases such as cancer as well as acute and chronic inflammation by specifically neutralizing the biological activity of a neutrophil-secreted matrix metalloproteinase (MMP). According to a preferred embodiment of the invention, the neutrophil-secreted MMP that is targeted is MMP-9 (gelatinase B). According to the invention, the beneficial effects conferred by the specific neutralization of a neutrophil-secreted MMP, and more particularly MMP-9, are not counterbalanced by the detrimental effects of a broad and non-specific inhibition of other MMPs.
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