TNF and IFN stimulated genes and uses therefor
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Issued Date -
Nov 7, 2002
app pub date -
May 11, 2001
filing date -
May 12, 2000
priority date (Note) -
Abandoned
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Abstract
The present invention is directed to the identification of genes that are expressed at a higher level in certain TNF & IFN treated cells than in otherwise identical untreated cells. Genes that are expressed at a higher level in TNF & IFN treated cells than untreated cells ('TNF & IFN stimulated genes') are of interest, in part, because TNF & IFN can or could influence a wide range of cellular processes and responses for antiviral activity. The identified TNF & IFN stimulated genes and the proteins they encode can be used: 1) as therapeutic agents which modulate a cellular process or response that is influenced by TNF & IFN; 2) as targets for use in high throughput screening and the development of therapeutic agents which modulate a cellular process or response that is influenced by TNF & IFN; and 3) as markers which can be used to detect and monitor a cellular process or response that is influenced by TNF & IFN.
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