Sequencing duplex DNA by mass spectroscopy
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United States of America Patent
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app pub date -
Mar 26, 2001
filing date -
Jun 6, 1994
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Abstract
For the determination of masses of macromolecular analytes with particular application to DNA sequencing by mass spectroscopy, novel strategies of sample preparation and labeling decrease macromolecule breakage, improve identification of population members, aid attainment of a single charge state for the heterogeneous analyte inputs, and increase the sensitivity of detection of the fractionated macromolecules.
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