Enzyme-mediated modification of fibrin for tissue engineering
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United States of America Patent
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Issued Date -
Nov 14, 2002
app pub date -
Dec 18, 2001
filing date -
Apr 3, 1997
priority date (Note) -
Abandoned
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Abstract
Matrices covalently bound to bidomain peptides or proteins, produced recombinantly or synthetically, contain a transglutaminase substrate domain and a bioactive factor. The bioactive factor is preferably a growth factor, such as VEGF, growth factors from the TGF-.beta. superfamily, PDGF, human growth hormone, IGF, and ephrin. Particularly preferred growth factors are TGF-.beta.1, BMP 2; VEGF.sub.121 and PDGF AB. The matrix material is crosslinkable, and may form a gel. These compositions are useful for tissue repair and regeneration.
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