Replication competent AAV helper functions
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Issued Date -
Nov 28, 2002
app pub date -
Aug 10, 2001
filing date -
Aug 10, 2000
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention provides methods and compositions for the production of high titer, wild-type-free recombinant AAV ('rAAV') virions. The compositions of the present invention include novel nucleic acids encoding replication competent but packaging defective AAV helper functions and AAV helper function vectors. The present invention also includes host cells transfected by the claimed nucleic acids, methods of using the claimed vectors, and rAAV virions produced by such methods. The similar strategy can also be used for autonomous parvovirus virion production.
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