Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
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United States of America Patent
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Mar 15, 2005
Grant Date -
Dec 5, 2002
app pub date -
Dec 13, 2001
filing date -
Jun 10, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides an improved process for the preparation of a agglomerated solid dosage form, comprising: (1) preparing an aqueous slurry of (a) microcrystalline cellulose; (b) a microcrystalline cellulose compressibility augmenting agent which (i) physically restricts the proximity of the interface between adjacent cellulose surfaces; (ii) inhibits interactions between adjacent cellulose surfaces, for example, via the creation of a hydrophobic boundary at cellulose surfaces; or (iii) accomplishes both (i) and (ii) above; and (c) an active agent; (2) thereafter drying the resultant aqueous slurry in a manner which inhibits quasi-hornification, thereby obtaining an agglomerated material which is directly compressible into a solid dosage form.
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