Method of identifying inhibitors of CDC25

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20020183249A1
SERIAL NO

09797500

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to polypeptides which comprise the ligand binding domain of Cdc25, crystalline forms of these polypeptides and the use of these crystalline forms to determine the three dimensional structure of the catalytic domain of Cdc25. The invention also relates to the use of the three dimensional structure of the Cdc25 catalytic domain in methods of designing and/or identifying potential inhibitors of Cdc25 activity, for example, compounds which inhibit the binding of a native substrate to the Cdc25 catalytic domain.

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Patent Owner(s)

Patent OwnerAddress
TAYLOR NEIL RNot Provided

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blanchard, Jill Arlington, MA 3 47
Bockovich, Nicholas Malden, MA 7 32
Borhani, David Worcester, MA 3 41
Choquette, Deborah Rutland, MA 22 1018
Come, Jon Cambridge, MA 19 649
Dixon, Richard W Jefferson, MA 48 2337
Eckstein, Jens Arlington, MA 4 35
Epstein, David Belmont, MA 61 858
Fujimori, Taro Shrewsbury, MA 2 42
Haupt, Andreas Schwetzingen, DE 99 682
Hediger, Mark Marlboro, MA 1 23
Kluge, Arthur Lincoln, MA 30 143
Pal, Kollol Needham, MA 26 193
Ritter, Kurt Newton, MA 59 1606
Robinson, Simon Stow, MA 21 442
Rudolph, Johannes Durham, NC 6 36
Taylor, Neil R Sydney, AU 8 242
Walker, Nigel Burlingame, CA 12 178

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