Systems and methods for introducing samples into microfluidic devices
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United States of America Patent
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Issued Date -
Dec 12, 2002
app pub date -
Jun 3, 2002
filing date -
Jun 7, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
A pressure-driven microfluidic device for separating chemical or biological species from a sample includes on-column injection, namely, a separation channel containing stationary phase material and a sample input disposed between a first end and a second end of the separation channel or column. One or many separation channels may be provided in a single microfluidic device, which may be fabricated with sandwiched stencil layers using various materials including polymers. Sealing means associated with a sample input, such as a mechanical seal adapted to selectively seal the sample input, are provide. Various sample injector configurations are provided. A separation system including a microfluidic device having on-column injection further includes a pressure source and a detector.
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