Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
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United States of America Patent
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N/A
Issued Date -
Dec 19, 2002
app pub date -
Oct 3, 2001
filing date -
Mar 27, 2001
priority date (Note) -
Abandoned
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Abstract
Biodegradable ABA-type or BAB-type triblock copolymers are disclosed that, at functional concentrations, are capable of solubilizing drugs, especially hydrophobic drugs, in a hydrophilic environment to form a solution at relevant temperatures for parenteral and particularly intravenous administration (temperatures of between at least 35 and 42.degree. C.) as well as all other routes of administration benefiting from an aqueous drug solution. The copolymers are comprised of about 50.1 to 65% by weight of biodegradable hydrophobic A polymer block(s) comprising a biodegradable polyester, and about 35 to 49.9% by weight of a biodegradable hydrophilic B polymer block comprising a polyethylene glycol (PEG), and wherein the triblock copolymer has a weight-averaged molecular weight of between about 2400 to 4999.
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