Methods for assessing antiangiogenic agents
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United States of America Patent
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Feb 23, 2010
Grant Date -
Dec 19, 2002
app pub date -
May 9, 2002
filing date -
May 11, 2001
priority date (Note) -
Expired
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Abstract
We have discovered that endothelial progenitor cells (EPC) are particularly suitable for use in a sensitive assay for antiangiogenic factors. We have found that EPC mobilization and differentiation is greatly inhibited by antiangiogenic factors as evidenced in vivo by VEGF inducing a massive mobilization of EPC into the blood circulation which effect is significantly inhibited by endostatin treatment, and, in vitro, human blood-derived EPC forming adherent colonies, which colonies, in the presence of angiogenic factors, give rise to differentiated EC, and which differentiation is disrupted and cell growth is inhibited in the presence of angiostatin and endostatin.
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