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Abstract

Tissue-engineered bio-active cardiac constructs (BACCs) are described. These constructs are prepared by combining a suspension of isolated cells with a suitable support such as an extra-cellular filament or matrix. The isolated-cell component of the constructs is prepared from mammalian cardiac tissue, or from cells that differentiate into cardiac tissue. Extra-cellular filaments and/or matrices are prepared from naturally-occurring or synthetic polymers and may be biodegradable or non-biodegradable, depending on the application. Bio-active cardiac constructs are prepared in suspension culture using a defined, serum-free medium. Bio-active cardiac constructs are functionally and morphologically similar to intact cardiac tissue and may be used as tissue equivalents for research or drug testing applications, as well as in surgical applications for the treatment of heart disease.

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