System for osmotic delivery of pharmaceutically active agents
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United States of America Patent
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-
Jan 4, 2005
Grant Date -
Jan 2, 2003
app pub date -
Jun 1, 2001
filing date -
Jun 1, 2001
priority date (Note) -
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status (Latency Note)
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Abstract
An osmotic system for delivering a pharmaceutically active agent which comprises a core portion, a layer portion enclosing the core portion, and a semipermeable wall portion enclosing the core portion and the layer portion. The core portion includes the pharmaceutically active agent at a first concentration. The pharmaceutically active agent is present in the layer portion at a second concentration. The second concentration is greater than the first concentration. Such a system provides for the osmotic release of the pharmaceutically active agent in release profile other than a zero order release profile, and wherein the release profile is similar to or approaches or reaches a first order release profile.
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