METHODS AND COMPOSITIONS FOR IDENTIFYING RECEPTOR EFFECTORS

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United States of America Patent

SERIAL NO

09201396

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Abstract

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The present invention makes available rapid, effective assays for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assays enable rapid screening of large numbers of polypeptides in a library to identify those polypeptides which induce or antagonize receptor bioactivity. The subject assays are particularly amenable for identifying agonists and antagonists for orphan receptors. In particular the present invention makes available novel ligand agonists of human formyl peptide receptor like-1 (FPRL-1) receptors. These novel ligand agonists are used in the assays of the invention to identify modulators of FPRL-1 receptor.

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Patent Owner(s)

Patent OwnerAddress
CADUS TECHNOLOGIES INC767 FIFTH AVENUE NEW YORK NY 10153

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
KLEIN, CHRISTINE A OSSINING, NY 10 69
MURPHY, ANDREW JM MONTCLAIR, NJ 5 13
PAUL, JEREMY NYACK, NY 12 153

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