Method and apparatus for stimulating angiogenesis and wound healing by use of external compression

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United States of America Patent

APP PUB NO 20030009119A1
SERIAL NO

09815528

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A system for delivering external compression in order to stimulate angiogenesis or promote wound healing is provided. External compression causes changes in hemodynamic forces (e.g., shear stress) in the vasculature that are sensed by endothelial cells and smooth muscle cells. The stimulated cells respond by secreting various angiogenic factors and growth factors such as platelet-derived growth factors A and B and basic fibroblast growth factor. The inventive method may be used to treat patient suffering from diseases characterized by low blood flow such as peripheral vascular disease and coronary artery disease. A apparatus for delivering external compression to induce angiogenesis or promote wound healing is also provided.

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Patent Owner(s)

Patent OwnerAddress
GENERAL HOSPITAL CORPORATION THE55 FRUIT STREET BOSTON MA 02114

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gertler, Jonathan P Weston, MA 1 25
Kamm, Roger D Weston, MA 11 574

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