VPR-DRIVEN DNA OR RNA CONSTRUCT AND THERAPEUTIC USES THEREOF
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United States of America Patent
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Issued Date -
Jan 23, 2003
app pub date -
Jul 22, 1998
filing date -
Jul 22, 1998
priority date (Note) -
Abandoned
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Abstract
The present invention relates to a DNA or RNA construct capable of expression of IL-2 in a warm-blooded animal or biological preparation, the recombinant DNA or RNA construct comprising a) a Vpr activated promoter; b) a transcribable DNA segment coding for IL-2 and; c) a secretory DNA encoding for a signal peptide functional in mammary cells and operably linked between the promoter and the DNA segment to facilitate secretion of the IL-2. The present invention also relates to a method for increasing the immune response of a warm-blooded animal or biological preparation. There is also described methods for inhibiting or stimulating expression of IL-8 of a warm-blooded animal or a biological preparation.
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