Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same

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United States of America Patent

PATENT NO 6828305
APP PUB NO 20030027995A1
SERIAL NO

09873757

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Abstract

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Mixtures of conjugates in which each conjugate in the mixture comprises a growth hormone drug coupled to an oligomer that includes a polyalkylene glycol moiety wherein the mixtures have a molecular weight distribution with a standard deviation of less than about 22 Daltons are disclosed. Methods of treating growth hormone deficiency in a subject in need of such treatment and methods of accelerating the growth rate of an animal arc also disclosed. Processes for synthesizing substantially monodispersed mixtures of conjugates wherein each conjugate comprises a growth hormone drug coupled to an oligomer that comprises a polyethylene glycol moiety are further provided.

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Patent Owner(s)

  • BIOCON LIMITED

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ansari, Aslam M Rockville, MD 16 333
Ekwuribe, Nnochiri N Cary, NC 63 1229
Odenbaugh, Amy L Morrisville, NC 17 228
Price, Christopher H Chapel Hill, NC 28 480

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