Lipid-mediated polynucleotide administration to deliver a biologically active peptide and to induce a cellular immune response
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United States of America Patent
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Jul 31, 2007
Grant Date -
Feb 13, 2003
app pub date -
Jul 26, 2002
filing date -
Mar 21, 1989
priority date (Note) -
Expired
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Abstract
A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
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