Optimized procedures for the manufacture of paroxetine salts
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United States of America Patent
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Issued Date -
Feb 13, 2003
app pub date -
Apr 25, 2002
filing date -
Apr 25, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Described herein are methods for manufacturing amorphous paroxetine hydrochloride by mixing a carboxylic acid salt of paroxetine with hydrogen chloride and isolating the amorphous paroxetine hydrochloride. Also described herein are methods for manufacturing substantially pure paroxetine free base and methods for obtaining paroxetine salts such as paroxetine acetate, paroxetine trifluoroacetate, and paroxetine formate. Also described are methods for preparing paroxetine carbonate, paroxetine phosphate, paroxetine sulfate, and analogous salts thereof. The paroxetine salts may be formulated for the treatment of medical disorders as described.
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