Methods for generating an mRNA expression profile from an ecellular mRNA containing blood sample and using the same to identify functional state markers
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United States of America Patent
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Issued Date -
Feb 20, 2003
app pub date -
May 31, 2002
filing date -
May 31, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Methods for generating an mRNA expression profile are provided. In the subject methods, a population of nucleic acid targets is first generated from an acellular blood sample that contains a plurality of distinct mRNAs, i.e., a disease specific particular blood fraction. The resultant nucleic acid targets are hybridized to an array of nucleic acid probes to obtain an mRNA expression profile. The subject mRNA expression profiles are useful in the identification of disease specific markers. In such applications, the mRNA expression profiles are compared to a control expression profile to identify disease specific markers, where the identified markers subsequently find use in diagnostic applications. The subject methods also find use in diagnostic applications, where the mRNA expression profile is compared to a reference in making a diagnosis of the presence of a disease condition. Finally, kits for use in practicing the various methods are provided.
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