Method of treating wounds by enhancing expression of procollagen
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United States of America Patent
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Issued Date -
Mar 13, 2003
app pub date -
Jan 29, 2002
filing date -
Jan 29, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention provides methods for identifying compounds useful for the treatment of wounds by determining whether the compound increases the expression of type I procollagen and/or type III procollagen by human fibroblasts cultured in the presence of collagen. The present invention also provides methods for treating wounds by applying to the wound and/or surrounding tissue a therapeutically effective amount of anabolic steroid in a pharmaceutically acceptable formulation, wherein the steroid is not administered systemically to a patient. The present invention also provides compositions comprising at least one anabolic steroid in an amount effective to promote collagen production in at the site of a wound, wherein the composition is a pharmaceutically acceptable formulation suitable for local administration.
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