Compositions and methods for producing antibodies to low molecular weight analytes
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United States of America Patent
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Issued Date -
Mar 13, 2003
app pub date -
Dec 12, 2001
filing date -
Dec 15, 2000
priority date (Note) -
Abandoned
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Abstract
Improved immunogenic compositions and methods for producing antibodies to low molecular weight analytes are presented. In one series of embodiments particularly useful for production of antibodies having specificity for metal ions, nonimmunogenic polymers having natural metal ion-binding activity, typically alginates, are used, after contact with metal ions, as an immunogenic composition. In another series of embodiments, immunogens are enmeshed in a crosslinked protein network to create a potent immunogenic composition. In the latter embodiments, gelatins of cold-water fish prove surprisingly efficacious.
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