Combinatorial protecting group strategy for multifunctional molecules
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United States of America Patent
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Issued Date -
Mar 20, 2003
app pub date -
Jul 31, 2002
filing date -
Apr 17, 1996
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Abandoned
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Abstract
In general, the invention features the use of novel protection schemes and solid phase synthesis reactions to generate molecules of core structure M, which have a plurality of moieties, each of which can be individually deprotected or subsequently derivatized. In a preferred process, M is a multifunctional low molecular weight compound, such as a saccharide, aminosugar, deoxysugar, nucleoside, nucleotide, coenzyme, amino acid, lipid, steroid, vitamin, hormone, alkaloid, or small molecule drug. In a particularly preferred process, M is an oligomeric compound (e.g. a oligosaccharide, oligonucleotide, peptide or protein).
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