Formulations comprising dehydrated particles of pharmaceutical agents and process for preparing the same
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United States of America Patent
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N/A
Issued Date -
Mar 27, 2003
app pub date -
Aug 16, 2002
filing date -
Jun 4, 1999
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
A formulation for non-invasive delivery of pharmaceutical agents, particularly proteins and peptides, by absorption through a membrane at a targeted site is provided, along with a process of making the formulation. The formulation comprises a suspension of solid-phase dehydrated particles in a delivery medium. The particles comprise the dehydration product of the pharmaceutical agent and at least one of a surfactant and permeation enhancer, and the delivery medium preferably comprises a propellant for pressurized aerosol delivery of the formulation. The formulation can be conveniently delivered to the patient's targeted site where the pharmaceutical agent is absorbed through the mucosa to achieve a desired bioavailability.
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