Stabilized nanoparticle formulations of camptotheca derivatives
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United States of America Patent
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Issued Date -
Mar 27, 2003
app pub date -
Jun 6, 2002
filing date -
May 11, 1998
priority date (Note) -
Abandoned
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Abstract
Pharmaceutical formulations are provided that increase the systemic bioavailability of camptotheca derivatives; preferably, the camptothecin derivative is 7-ethyl-10-hydroxyl camptothecin, SN-38. The drug is complexed with a stabilizing agent, but is not covalently bound thereto. Anionic or neutral lipids and/or polymers are used as the stabilizing agent, and secondary stabilizing agents and/or other excipients may be incorporated into the formulation as well. Therapeutic methods are also provided, wherein a formulation of the invention is administered to a patient to treat a condition, disorder, or disease that is responsive to camptothecin derivatives. Generally, administration is oral or parenteral.
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