Methods for in vivo evaluation of respiratory or cardiopulmonary disorders such as chronic heart failure using polarized 129Xe
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United States of America Patent
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Issued Date -
Apr 3, 2003
app pub date -
Sep 6, 2002
filing date -
Sep 20, 2001
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Abandoned
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Abstract
In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized .sup.129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue: (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.
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