Method of delivering drugs to a tissue using drug-coated medical devices
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United States of America Patent
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N/A
Issued Date -
Apr 3, 2003
app pub date -
Feb 14, 2002
filing date -
Oct 2, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention relates to a method of delivering drugs having anti-proliferative activity in the cardiovascular system to a tissue or circulation using a drug-coated medical device. The drug-coated medical device is brought into contact with the target tissue or circulation and the drugs are quickly released into the area surrounding the device in a short time after the contact step. The release times may include 30 seconds, 1 minute or 3 minutes. Once the therapeutic drugs are released, they are quickly and effectively absorbed by the surrounding cells or circulation. The therapeutic drug may have sustained anti-proliferative activity and thus a prolonged effect. The therapeutic drug, which inhibits proliferative activity in the cardiovascular system, may be preferably encapsulated in a controlled release carrier. In a preferred embodiment, the controlled release carrier may be a liposome, drug aggregate, microparticle or nanoparticle and the therapeutic agent may be a bisphosphonate.
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