Method and apparatus for increasing flux during reverse iontophoresis
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United States of America Patent
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Issued Date -
Apr 3, 2003
app pub date -
Jul 23, 2001
filing date -
Jul 23, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention provides a method and device that substantially increases reverse iontophoretic flux and therefore, noninvasive extraction of uncharged and charged permeant molecules alike through the skin. By substituting the mobile co-ions, which are capable of easily entering the pores from the receiver compartment of a reverse iontophoretic extraction device with large conductive polyelectrolytes within the reservoir that do not appreciably enter the pores, the invention significantly improves the amount of analyte extracted, improves device performance, decreases energy requirements, increases battery life, reduces the potential for irritation, and improves accuracy, reproducibility, and precision.
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