IDIOTYPIC VACCINATION AGAINST B CELL LYMPHOMA
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United States of America Patent
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Issued Date -
Apr 17, 2003
app pub date -
Mar 14, 1990
filing date -
Mar 14, 1990
priority date (Note) -
Abandoned
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Abstract
The invention provides a method of inducing an effective immune response to pathogenic lymphocytes by administering dendritic cells previously pulsed with the idiotype protein of interest. In one embodiment, a method for the active immunization of a mammal against lymphoma is provided. This embodiment comprises exposing dendritic cells to idiotype Ig to make idiotype pulsed dendritic cells and injecting the idiotype pulsed dendritic cells back into the mammal, whereby immunity against lymphoma cells is induced. In another embodiment, the invention relates to the administration of both idiotypic cells and pulsed dendritic cells.
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