Solid state sensing system and method for measuring the binding or hybridization of biomolecules
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United States of America Patent
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Issued Date -
Apr 17, 2003
app pub date -
Jul 23, 2002
filing date -
Oct 12, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Measurements relating to the activity of various molecules of interest are obtained using a sensing surface with an associated first charge, a charge-regulating layer bound to the sensing surface, various possible probe molecules and a measurement circuit. The sensing surface has a layer bound to it that confers a neutral charge or a second charge on a net basis. In addition, a probe is bound to at least one of the surface and the layer, the probe being complementary to and interacting with a molecule of interest. The interaction between the probe and the molecule of interest is detected electrically.
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