Oligonucleotides labeled with stable isotopes and a method for detecting the same
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United States of America Patent
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Issued Date -
Apr 17, 2003
app pub date -
Mar 28, 2000
filing date -
Mar 31, 1999
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Abstract
Antisense oligonucleotide sequences which enable the measurement of the distribution and structure of antisense oligonucleotide drugs in the body, with lapse of time, and a method of detecting these sequences are provided. The antisense chains have a natural or non-natural nucleotide or peptide nucleic acid as a structure unit in which carbon atoms and nitrogen atoms are substituted by .sup.13C and .sup.15N, respectively, and the antisense chains can be detected by nuclear magnet resonance spectrometry (NMR) such as .sup.15N--.sup.1H or .sup.13C--.sup.1H heteronuclide multiple quantum coherence spectrometry.
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