Importance

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Abstract

Medical devices such as intracoronary stents coated with a therapeutic substance are disclosed. In a preferred embodiment, an arterial site with obstructive coronary artery disease is treated via a therapeutic substance applied to an intraluminal stent and placed locally in the coronary artery. Improved porous designs polymeric films and coatings for stents, with or without a therapeutic substance, are also disclosed. By providing a separate sleeve and stent, various bioactive materials can be impregnated into the sleeve and combined with the stent, providing greater variety to treatment options, and significant improvements in regulatory protocols as new bioactive or therapeutic materials are produced. The present invention provides a stent that has a substrate and a degradable sleeve, and the sleeve itself is made of a carrier material, such as the polymeric materials and a bioactive compound. Certain bioactive materials have been found to be useful for impregnation into stent coatings or sleeves, such as rolipram, phosphodiesterase type IV inhibitors, curcumin, adenosine and adenosine receptor type 2A agonists, all of which have now been found to significantly reduces restenosis. Alternatively, the present invention, in another aspect, also relates to the promotion of angiogenesis on stents, by inserting a stent into a vessel where the stent has a substrate and a coating, wherein the coating is selected from the group: retinoic acid, Matrigel, laminin and laminin derived peptides.

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First Claim