Use of ribozymes for functionating genes
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United States of America Patent
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Issued Date -
May 8, 2003
app pub date -
Sep 16, 2002
filing date -
Feb 13, 1998
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Abandoned
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Abstract
Methods and compositions for identifying a gene or genes associated with the generation of a specific cellular phenotype or a specific cellular response using combinatorial libraries of catalytic RNA directed against RNA sequences encoding structural or functional polypeptide motifs. The invention is exemplified by use of a combinatorial ribozyme library to target sequence in mRNAs encoding zinc finger, protein kinase and integrin motifs.
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