Compositions and methods for delivery of poorly water soluble drugs and methods of treatment
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United States of America Patent
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Issued Date -
May 8, 2003
app pub date -
Oct 15, 2002
filing date -
Oct 15, 2001
priority date (Note) -
Abandoned
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Abstract
The present embodiment of the invention is generally directed to compositions comprising suspensions of poorly water soluble compounds recrystallized in nanoparticulate sizes ranging from 0.1 to 5 .mu.m. In addition, the embodiment of the invention is directed to methods for preparation and administration of these compositions to a patient for prevention and treatment of disease states. In particular, the embodiment of the invention is directed to compositions comprising suspensions of poorly water-soluble compounds, such as antimitotics and antibiotics, in nanoparticulates and methods of prevention and treatment of chronic disease states, such as cancer, by intraperitoneal and intravenous administration of such compositions.
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