Elk1 phosphorylation related gene
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United States of America Patent
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Issued Date -
May 15, 2003
app pub date -
Jul 18, 2002
filing date -
Jul 18, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Proteins having MAP kinase cascade activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of MAP kinase cascade are provided. Using the plasmids pFR-Luc and pFA2-Elk1, the cDNA encoding a protein capable of activating MAP kinase cascade was cloned from the cDNA library constructed from human lung fibroblasts, and the DNA sequence and the deduced amino acid sequence were determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful for screening a substance inhibiting or promoting activation of MAP kinase cascade.
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