Protopanaxadiol and protopanaxatriol and their use as anti-cancer agents
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United States of America Patent
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Issued Date -
May 15, 2003
app pub date -
Sep 21, 2001
filing date -
Sep 21, 2001
priority date (Note) -
Abandoned
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Abstract
The invention provides for the use of sapogenin protopanaxadiol and/or sapogenin protopanaxatriol in synergistic combination with another cancer chemotherapeutic in pharmaceutical compositions used in methods of inhibiting the multiplication of cancer cells, and methods of treating cancer in patients, comprising administering to such patients therapeutically and synergistically effective amounts of sapogenin protopanaxadiol and/or sapogenin protopanaxatriol in combination with a chemotherapeutic selected from the group consisting of paclitaxel and mitoxantrone. The cancer cells to be treated may be multi-drug resistant. The cancer cells may, for example, be prostate cancer cells or breast cancer cells.
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