Screening system for identifying drug-drug interactions and methods of use thereof

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United States of America Patent

APP PUB NO 20030096309A1
SERIAL NO

10223882

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention features a method of screening for drug-drug interactions using combinational arrays. The method includes the steps of: (a) providing (i) a test drug; (ii) a drug library; and (iii) an assay, (b) contacting the test drug and at least some of the library drugs from the drug library in the assay under conditions that ensure that each test drug/library drug contacting is segregated from the others, (c) recording the result of the contacting of the test drug and the library drug in the assay, and (d) identifying combinations of drugs that produce a result in the assay that is different from the results produced by either drug of the combination by itself. According to the method, each of the identified combinations indicates an interaction between the test drug and the library drug.

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Patent Owner(s)

Patent OwnerAddress
COMBINATORX INC245 FIRST STREET SIXTEENTH FLOOR CAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Borisy, Alexis Boston, MA 40 1372
Grau, Daniel Cambridge, MA 6 162
Keith, Curtis Boston, MA 37 590
Stockwell, Brent R Boston, MA 53 567

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