Streptavidin expressed gene fusions and methods of use thereof
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United States of America Patent
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Issued Date -
Jun 5, 2003
app pub date -
May 17, 2002
filing date -
Jun 7, 1999
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention provides vectors for expressing genomic streptavidin fusion cassettes. In the various embodiments, fusion proteins produced from these vectors are provided. In particular embodiments, fusion proteins comprising a single chain antibody and genomic streptavidin are provided as are vectors encoding the same. Also provided, are methods of using the fusion proteins of the present invention, in the absence and presence of a radiation-sensitizing agent, and in particular, the use of scFvSA fusion proteins as diagnostic markers or as a cell specific targeting agents.
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