Biosensors for single cell and multi cell analysis
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United States of America Patent
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Issued Date -
Jun 5, 2003
app pub date -
Nov 30, 2001
filing date -
Nov 30, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention relates to a structure comprising a biological membrane and substrate with fluidic network, an array of membranes and an array of fluidic networks in substrate, a high throughput screen, methods for production of the membrane, substrate structure, and a method for interconnected array of substrate structures and a method for attaching membranes to structure, a method to electrically record events from the membranes and a method to screen large compound library using the array. More particularly, it relates to biological cells and artificial cell membranes adhered to the substrate with a high electrical resistivity seal, a method to manufacture array configuration of such substrates, and a method to screen compounds using the membrane receptors such as ion-channels, ion pumps, & receptors.
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