Method for administration of a taxane/tocopherol formulation to enhance taxane therapeutic utility
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United States of America Patent
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Issued Date -
Jun 5, 2003
app pub date -
Jul 1, 2002
filing date -
Jan 7, 1997
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
The present invention provides methods for administering a taxane composition for the treatment of cancer. In one aspect, the compositions are not diluted prior to administration. Some embodiments provide methods for administering a taxane as a bolus injection or an intravenous infusion in less than about 30 minutes. In other aspects, the invention provides methods for administering a taxane to provide high concentrations of the taxane in blood or in tumors. Another aspect provides methods for administering a taxane to provide anti-tumor activities against solid tumors. In some embodiments, the methods provide anti-tumor activities against tumors that were resistant to conventional taxane administration methods. In some embodiments, the methods provide anti-tumor activities against colorectal tumors.
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