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Abstract

New 3-substituted 4-(phenyl-N-alkyl)-piperazine and 4-(phenyl-N-alkyl)-piperidine compounds of Formula (1) wherein X is N, CH, or C, however X may only be C when the compound comprises a double bond at the dotted line; R.sub.1 is OSO.sub.2CF.sub.3, OSO.sub.2CH.sub.3, SOR.sub.5, SO.sub.2R.sub.5, COR.sub.5, CN, NO.sub.2, CONHR.sub.5, CF.sub.3, 3-thiophene, 2-thiophene, 3-furane, 2-furane, F, Cl, Br, or I; R.sub.2 is a C.sub.1-C.sub.4 alkyl, an allyl, CH.sub.2SCH.sub.3, CH.sub.2CH.sub.2OCH.sub.3, CH.sub.2CH.sub.2CH.sub.2F, CH.sub.2CF.sub.3, 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl, or --(CH.sub.2)--R.sub.6; R.sub.3 and R.sub.4 are independently selected from the group consisting of H and C.sub.1-C.sub.4 alkyls, however both R.sub.3 and R.sub.4 cannot be H at the same time; R.sub.5 is C.sub.1-C.sub.3 alkyls, CF.sub.3, or N(R.sub.2).sub.2; R.sub.6 is a C.sub.3-C.sub.6 cycloalkyl, 2-tetrahydrofurane, or 3-tetra-hydrofurane, as well as pharmaceutically acceptable salts thereof are disclosed. Also pharmaceutical compositions comprising the above compounds and methods wherein the above compounds are used are disclosed.

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First Claim