Modified surface for carrying out or detecting affinity reactions
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United States of America Patent
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app pub date -
Sep 6, 2002
filing date -
Apr 15, 1998
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Abstract
A device for carrying out and/or detecting affinity reactions comprises at least one surface or boundary surface on which an affinity reaction can take place, and at least one polymer bound to the surface. According to the invention, this device is obtainable by bonding the polymer to the surface in its pure phase, i e. essentially free of solvents. The polymer is preferably a terminally homo- or heterosubstituted bifunctional polymer, a corresponding polyalkylene glycol, in particular a polyethylene glycol, being preferred. The surface can be made of a metal oxide, in particular silicon dioxide. Before bonding the polymer, an activation of the surface, preferably by introducing functional groups by means of a silanization, can be effected.
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