Methods of optimizing antibody variable region binding affinity

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United States of America Patent

APP PUB NO 20030120044A1
SERIAL NO

09982464

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention provides a method of conferring donor CDR binding affinity onto an antibody acceptor variable region framework. The invention also provides a method of simultaneously grafting and optimizing the binding affinity of a variable region binding fragment. A method of optimizing the binding affinity of an antibody variable region is also provided.

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Patent Owner(s)

Patent OwnerAddress
APPLIED MOLECULAR EVOLUTIONS [FORMERLY IXSYS INC ]3520 DUNHILL STREET SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huse, William D Del Mar, CA 79 2451
Watkins, Jeffry D Encinitas, CA 123 1786
Wu, Herren Houston, TX 110 2333

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