Bioactive absorbable microparticles as therapeutic vaccines
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United States of America Patent
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Issued Date -
Jul 3, 2003
app pub date -
Jul 8, 2002
filing date -
Jul 6, 2001
priority date (Note) -
Abandoned
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Abstract
A therapeutic vaccine for tumor immunotherapy is disclosed which comprises absorbable microparticles/nanoparticles capable of delivering immobilized stimulatory/costimulatory signals and releasing necessary cytokines to promote an anti-tumor effect. The microparticles/nanoparticles are formed of an absorbable crystalline polymer, preferably acid-terminated polyglycolide. Other bioactive agents such as tumor specific antigens, DNA or RNA may be immobilized of the surface of the particles.
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