Electronic sensing of chemical and biological agents using functionalized nanostructures

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United States of America Patent

APP PUB NO 20030134433A1
SERIAL NO

10345783

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention provides for an apparatus and a method for detecting the presence of pathogenic agents with sensors containing functionalized nanostructures integrated into circuits on silicon chips. The nanostructures are functionalized with molecular transducers that recognize and bind targeted analytes which are diagnostic of the pathogenic agent of interest. The molecular transducer includes a receptor portion, which binds the analyte, and an anchor portion that attaches to the nanostructure. Upon binding of the analyte, a change in molecular configuration represented by the newly formed receptor-analyte complex creates a force that is transmitted to the nanostructure via the anchor portion of the transducer. The effect of the force transmitted to the nanostructure is to alter its conductivity. The change in conductivity of the nanotube thus represents a signal that indicates the presence of the pathogenic agent of interest.

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Patent Owner(s)

Patent OwnerAddress
NANOMIX INC5980 HORTON STREET 6TH FLOOR EMERYVILLE CA 94608

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Collins, Philip Irvine, CA 10 100
Gabriel, Jean Christophe Pinole, CA 6 135
Gruner, George Los Angeles, CA 59 2398
Swanson, Basil Los Alamos, NM 3 93
Wudl, Fred Los Angeles, CA 49 520

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