Direct targeting binding proteins
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United States of America Patent
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Issued Date -
Aug 7, 2003
app pub date -
Oct 15, 2002
filing date -
Oct 15, 2001
priority date (Note) -
Abandoned
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Abstract
The present invention relates to multivalent, monospecific binding proteins. These binding proteins comprise two or more binding sites, where each binding site specifically binds to the same type of target cell, and preferably with the same antigen on such a target cell. The present invention further relates to compositions of monospecific diabodies, triabodies, and tetrabodies, and to recombinant vectors useful for the expression of these functional binding proteins in a microbial host. Also provided are methods of using invention compositions in the treatment and/or diagnosis of tumors.
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