Novel method for the production of anti-human antigen receptors and uses thereof
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United States of America Patent
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app pub date -
Dec 19, 2002
filing date -
Apr 14, 1997
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Abandoned
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Abstract
Described is a method for the production of an anti-human antigen receptor that is low or not immunogenic in humans comprising the steps of selecting a combination of functionally rearranged VH and VL immunoglobulin chains wherein at least said VH chain is derived from essentially unprimed mature human B-lymphocytes or from essentially anergic human B cells and said VL chain in derived from a naturally occurring human B cell repertoire, said chains being expressed from a recombinant vector and using an in vitro display system for binding to a human antigen.
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