Method for rendering streptokinase less immunogenic to a human
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United States of America Patent
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Oct 24, 2006
Issued Date -
N/A
app pub date -
Nov 20, 2002
filing date -
May 21, 1997
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Expired
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Abstract
Protein, or parts of proteins, may be rendered non-immunogenic, or less immunogenic, to a given species by identifying in their amino acid sequences one or more potential epitopes for T-cells of the given species and modifying the amino acid sequence to eliminate at least one of the T-cell epitopes. This eliminates or reduces the immunogenicity of the protein when exposed to the immune system of the given species. Monoclonal antibodies and other immunoglobulin-like molecules can particularly benefit from being de-immunised in this way: for example, mouse-derived immunoglobulins can be de-immunised for human therapeutic use.
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