Novel method for down-regulation of amyloid

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20030157117A1
SERIAL NO

10223809

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

Disclosed are novel methods for combatting diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protien (APP) or beta amyloid (A.beta.). Immunization is preferably effected by administration of analogues of autologous APP or A.beta., said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous A.beta. which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Also disclosed are nucleic acid vaccination against APP or A.beta. and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
H. LUNDBECK A/SVALBY-COPENHAGEN214

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Degan, Florence Dal Horsholm, DK 5 36
Jensen, Martin Roland Horsholm, DK 12 112
Koefoed, Peter Horsholm, DK 5 81
Nielsen, Klaus Gregorius Horsholm, DK 16 233
Rasmussen, Peter Birk Horsholm, DK 25 197

Cited Art Landscape

Patent Info (Count) # Cites Year
 
JANSSEN ALZHEIMER IMMUNOTHERAPY (3)
* 6787523 Prevention and treatment of amyloidogenic disease 81 1998
* 6761888 Passive immunization treatment of Alzheimer's disease 101 2000
* 6787637 N-Terminal amyloid-.beta. antibodies 87 2000
 
EPIMMUNE INC. (1)
* 5736142 Alteration of immune response using pan DR-binding peptides 84 1994
 
NEW YORK UNIVERSITY (2)
* 2002/0077,288 Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid beta for induction of an immune response to amyloid beta and amyloid deposits 11 2001
* 6713450 Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid .beta. for induction of an immune response to amyloid .beta. and amyloid deposits 52 2001
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
* 2011/0086,036 COMPOSITION COMPRISING VLP AND AMYLOID BETA PEPTIDE 0 2010
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (11)
8697082 Prevention and treatment of synucleinopathic and amyloidogenic disease 0 2004
8506959 Prevention and treatment of synucleinopathic and amyloidogenic disease 4 2005
* 2010/0031,377 Prevention and treatment of synucleinopathic and amyloidogenic disease 2 2005
* 9034337 Treatment and delay of outset of synucleinopathic and amyloidogenic disease 0 2007
* 2008/0014,194 Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease 27 2007
8147833 Prevention and treatment of synucleinopathic and amyloidogenic disease 6 2008
* 2010/0086,545 Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease 5 2008
8092801 Prevention and treatment of synucleinopathic and amyloidogenic disease 9 2008
* 2010/0278,814 Prevention and treatment of synucleinopathic and amyloidogenic disease 2 2008
* 2011/0135,660 PREVENTION AND TREATMENT OF SYNUCLEINOPATHIC DISEASE 7 2010
8673593 Antibodies to alpha-synuclein 0 2011
 
NOVARTIS AG (2)
8460676 Composition comprising VLP and amyloid beta peptide 0 2010
8617566 Composition comprising VLP and amyloid beta peptide 0 2013
 
SIEMENS AKTIENGESELLSCHAFT (2)
* 7850973 Peptide conjugate compositions and methods for the prevention and treatment of alzheimer's disease 0 2006
* 2009/0098,155 Peptide conjugate compositions and methods for the prevention and treatment of alzheimer's disease 1 2006
 
ABBVIE DEUTSCHLAND GMBH & CO. KG (2)
8895004 Method for the treatment of amyloidoses 0 2008
9176150 Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof 0 2011
 
ABBVIE INC. (9)
8691224 Anti-Aβ globulomer 5F7 antibodies 2 2006
8497072 Amyloid-beta globulomer antibodies 0 2006
8455626 Aβ conformer selective anti-aβ globulomer monoclonal antibodies 0 2007
8987419 Amyloid-beta binding proteins 0 2011
8877190 Aβ conformer selective anti-Aβ globulomer monoclonal antibodies 0 2011
9062101 Amyloid-beta binding proteins 0 2011
9359430 Abeta conformer selective anti-Abeta globulomer monoclonal antibodies 0 2013
9540432 Anti-Aβ globulomer 7C6 antibodies 0 2013
9394360 Aβ conformer selective anti-Aβ globulomer monoclonal antibodies 0 2014
 
PHARMEXA A/S (1)
* 2005/0163,744 Novel method for down-regulation of amyloid 12 2004
 
INTEZYNE TECHNOLOGIES, INC. (2)
7618944 Encapsulated amyloid-beta peptides 28 2008
* 2008/0274,965 ENCAPSULATED AMYLOID-BETA PEPTIDES 5 2008
 
Curix ApS (1)
* 2007/0172,496 Conjugates of amyloid proteins as vaccines for amyloid-related diseases 2 2005
 
UNIVERSITY OF SOUTH FLORIDA (1)
8188046 Amyloid beta peptides and methods of use 0 2007
 
ELAN PHARMACEUTICALS, INC. (1)
* 2009/0035,217 Truncated Fragments of Alpha-Synuclein in Lewy Body Disease 1 2008
 
H. LUNDBECK A/S (5)
7135181 Method for down-regulation of amyloid 19 2001
* 2003/0086,938 Novel methods for down-regulation of amyloid 32 2002
* 2009/0092,579 NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID 1 2008
8871212 Amyloid-beta polypeptide vaccine 0 2008
* 2010/0047,262 NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID 0 2008
 
Pharnexa A/S (1)
* 2007/0041,945 NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID 3 2006
 
GLAXOSMITHKLINE BIOLOGICALS SA (1)
* 2012/0321,694 COMPOSITIONS AND USES 0 2012
* Cited By Examiner