Sequestered antagonist formulations
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United States of America Patent
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N/A
Issued Date -
Aug 21, 2003
app pub date -
Aug 6, 2002
filing date -
Aug 6, 2001
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
Disclosed is an oral dosage form comprising (i) an opioid agonist in releasable form and (ii) a sequestered opioid antagonist which is substantially not released when the dosage form is administered intact, such that the ratio of the mean Cmax of the antagonist after single dose oral administration of the dosage form after tampering to the mean Cmax of antagonist after single dose oral administration of an intact dosage form is at least 1.5:1.
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