Method for identifying compounds altering higher-order chromatin-dependent chromosome stability
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United States of America Patent
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Issued Date -
Aug 21, 2003
app pub date -
Dec 20, 2002
filing date -
Jun 9, 2000
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Abstract
A method for identifying compounds that alter higher order chromatin dependent chromosome stability is based on determining the compounds' ability to modify a methyltransferase with Suv39h-like methyltransferase activity. The identified compounds are useful in therapy, in particular the therapy of human cancer and for contraception.
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